Acoustic-based fluid mixing

Figure 5: (a) Schematic of the acoustic-based mixing device. This device includes a PDMS microfluidic channel and a piezoelectric transducer. (b) Schematic showing the acoustic streaming phenomenon around the tip of an acoustically oscillated sharp-edge. (c) Schematic showing the design of the channel and sharp-edge.

Rapid and homogeneous mixing inside a microfluidic channel is demonstrated via the acoustic streaming phenomenon induced by the oscillation of sidewall sharp-edges. By optimizing the design of the sharp edges, we achieved excellent mixing performance and fast mixing speed in a simple device, making our sharp-edge-based acoustic micromixer a promising candidate for a wide variety of applications.


Po-Hsun Huang, Yuliang Xie, Daniel Ahmed, Joseph Rufo, Nitesh Nama, Yuchao Chen, Chung Yu Chan, and Tony Jun Huang, An acoustofluidic micromixer based on oscillating sidewall sharp-edgesLab on a Chip, Vol. 13, pp. 3847-3852, 2013. [PDF]

Po-Hsun Huang, Liqiang Ren, Nitesh Nama, Sixing Li, Peng Li, Xianglan Yao, Rosemarie A. Cuento, Cheng-Hsin Wei, Yuchao Chen, Yuliang Xie, Ahmad Ahsan Nawaz, Yael G. Alevy, Michael J. Holtzman, J. Philip McCoy, Stewart J. Levine and Tony Jun Huang, An acoustofluidic sputum liquefierLab on a Chip, Vol. 15, pp. 3125-3131, 2015. [PDF]

Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, and Tony J. Huang, A sharp-edge-based acoustofluidic chemical signal generator,  Lab on a Chip, accepted, 2018. [PDF]